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王平

1,基本信息:

姓名: 王平
职称:特别研究员
电话:021-54743264
邮箱:wangp1[at]sjtu.edu.cn 

主页:/usercenter.php?t=3
通讯地址:上海市东川路800号 化学B楼228

2. 教育经历
1996-2000:  南京大学化学系,学士
2000-2005:  中国科学院上海有机化学研究所,博士,导师:俞飚 研究员

3. 工作经历
2005-2008:  美国伯纳姆医学研究所,博士后,导师: Peter H.Seegerber 教授
2008-2013:  纪念斯隆凯特琳癌症中心,博士后、资深研究科学家,导师: Samuel J.Danishefsky 教授
2013-2016.2:  波士顿WARP DRIVE BIO 生物技术公司,研究科学家
2016.3- :  很很鲁很很鲁视在线视频|香蕉伊人不卡在线看|天天鲁啪视频在线,特别研究员

4. 研究方向
1)化学合成具有重要生理活性的糖蛋白、糖肽
2
)糖类分子合成及其方法学研究
3
)多肽合成方法学研究

5. 代表性论文

Publications

 

1.       Hongli Yin, Mengjie Zheng, Huan Chen, Siyao Wang, Qingqing Zhou, Qiang Zhang and Ping Wang*Stereoselective and divergent construction of -thiolated/selenolated amino acids via photoredox-catalyzed asymmetric Giese reaction. J. Am. Chem. Soc. 2020. Just accepted.

2.       Xiaoping Chen, Xiaosheng Luo, Xiao Peng, Jiaojiao Guo, Jiantao Zai and Ping Wang* Catalyst-Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro-Induced Radical Formation. Chemistry - A European Journal 2020, 15, 3226-3230.

3.       Dan Lu, Siyao Wang, Hongli Yin, Fengting Chu, Quhao Wei and Ping Wang* Rapid assembly of oligosaccharides via hydrophobic tag-assisted liquid-phase method. Synlett. 2020, doi.org/10.1055/s-0040-1707965.

4.       Dan Lu, Hongli Yin, Siyao Wang, Feng Tang, Wei Huang and Ping Wang* Chemical synthesis of homogeneous granulocyte-macrophage colony-stimulating factor through Se-auxiliary-mediated ligation. J. Org. Chem. 2020, 85, 1652-1660.

5.       Xiaoping Chen, Farong Ye, Xiaosheng Luo, Xueyi Liu, Jie Zhao, Siyao Wang, Qingqing Zhou, Gong Chen and Ping Wang* Histidine-Specific Peptide Modification via Visible-Light-Promoted C-H Alkylation. Accepted, J. Am. Chem. Soc. 2019. (Highlighted by SYNFACTs)

6.       Xueyi Liu, Jiazhi Liu, Zhichao Wu, Liangbiao Chen, Siyao Wang and Ping Wang*, A Photo-Cleavable Purification/Protection Handle Assisted Synthesis of Giant Modified Proteins with Tandem Repeats. Chem. Sci. 2019,10, 8694–8700.

7.       Siyao Wang, Yogesh Abaso Thopate, Qingqing Zhou and Ping Wang* Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof. Chin. J. Chem. 2019, DOI: 10.1002/CJOC. 201900246.

8.       Hongli Yin, Dan Lu, Siyao Wang, and Ping Wang* Development of Powerful Auxiliary-Mediated Ligation to Facilitate Rapid Protein Assembly. Org. Lett. 2019, 21, 51385142. (Highlighted by SYNFACTs)

9.       Kaiqian Wang, Xiaoping Chen, Xiao Peng, Ping Wang* and Feng Liang* A highly selective H/D exchange reaction of 1,4-dihydropyridines. Org. Biomol. Chem. 2019, 17, 3845–3852.

10.    Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi,Xian-Wei Liu, Guofeng Gu, Shu-Qi Wang, Jie Zhao, Ping Wang, Min Xiao, Fengshan Wang andHongzhi Cao. Reprogramming the enzymatic assembly line for site-specific fucosylation. Nature Catal. 2019, 2, 514–522.

11.    Huiyu Luo, Hongli Yin, Chaojun Tang, Ping Wang*, Feng Liang* Synthesis of cyclic peptide reniochalistatin E and conformational isomers. Chin. Chem. Lett. 2018, 29,1143–1146.


Before 2018

12.    Ping Wang, Suwei Dong, Jaehung Shieh, Ronald C. Hendrickson, Malcolm A. Moore, Samuel J. Danishefsky. Erythropoietin Derived by Chemical Synthesis. Science. 2013, 342, 1357-1360.
13.    Rebecca M. Wilson, Suwei Dong, Ping Wang and Samuel J. Danishefsky. The Winding Pathway to Erythropoietin: Success At Last, Angew. Chem. Int. Ed. 2013, 52.
14.    Xiaoyu Yang, Ping Wang, Biao Yu. Tacking the challenges in the Total Synthesis of Landomycin A. The Chemical Record. 2013, 13, 70-84.
15.    Ping Wang, Suwei Dong, Karthik Iyer, John A. Brailsford, Steve D. Townsend, Qiang Zhang, Ronald C. Hendrickson, Jaehung Shieh, Malcolm A. Moore, Samuel J. Danishefsky. At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51, 11576–11584. (Cover of the Journal, Highlighted by Science, Nature, Angew. Chem. Int. Ed., Chemistry World, Chemistry Views, C&EN NEWS)
16.    Ping Wang, Baptiste Aussedat, Yusuf Vohra and Samuel J. Danishefsky. An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation. Angew. Chem. Int. Ed. 2012, 51, 11571–11575.
17.    Rebecca M. Wilson, Jennifer L. Stockdill, Paul A. Vadola, Xiangyang Wu, Xuechen Li, Peter Park, Ping Wang and Samuel J. Danishefsky. A Journey into History: Exploration of the Fascinating World of Isonitriles. Angew. Chem. Int. Ed. 2012, 51, 2–17.
18.    Toshiaki K. Shibata, Fumiko Matsumura, Ping Wang, ShinYi Yu, Kai-Hooi Khoo, Kazuko Kitayama1, Tomoya O. Akama1, Kazuhiro Sugihara, Kyoko Kojima-Aikawa, Peter H. Seeberger, Minoru Fukuda, Atsushi Suzuki, Daisuke Aoki, and Michiko N. Fukuda.  Identification of mono- and di-sulfated N-acetyl-lactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer.J. Biol. Chem.2012, 287, 6592-6602.
19.    Ping Wang, Xuechen Li, Jianglong Zhu, Jin Chen, Yu Yuan, Xiangyang Wu, Samuel J. Danishefsky. Encouraging Progress in the -Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides. J. Am. Chem. Soc. 2011. 133, 1597-1602.
20.    Ping Wang and Samuel J. Danishefsky. A Promising General Solution to the Problem of Ligating Peptides and Glycopeptides. J. Am. Chem. Soc. 2010. 132, 17045-17051.
21.    Xiangyang Wu, Jennifer L. Stockdill, Ping Wang and Samuel J. Danishefsky. Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions. J. Am. Chem. Soc. 2010. 132, 4098-4100. (Highlighted by C&EN NEWS)
22.    Jin Chen, Ping Wang, Jianglong Zhu, Qian Wan and Samuel, J. Danishefsky. A Program for Ligation at Threonine Sites: Application to the Controlled Total Synthesis of Glycopeptides. Tetrahedron, 2010, 66, 2277-2283. (Cover of the Journal) 
23.    Ping Wang, Jianglong Zhu, Yu Yuan and Samuel, J. Danishefsky.Total Synthesis of the 2, 6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc. 2009, 131, 16669-16671. 
24.    Heeseob Lee, Ping Wang (co-first author), Motohiro Kobayashi, Jun Nakayama, Peter H. Seeberger and Minoru Fukuda. Cholesterol a-glucosyltransferase unique to Helicobacter pylori sequentially acts on donor and acceptor substrates:  Implication for the mode of actions by therapeutic inhibitors. Glycobiology. 2008, Jul; 18(7):549-58. Epub 2008 May 5.
25.    Ping Wang, Heeseob Lee, Minoru Fukuda and Peter H. Seeberger. One-pot synthesis of a pentasaccharide with antibiotic activity against Helicobacter pylori. Chem. Commun., 2007, 1963-1965.
26.    Heeseob Lee, Motohiro Kobayashi, Ping Wang, Jun Nakayama, Peter H. Seeberger and Minoru Fukuda. Expression cloning of cholesterol alpha -glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori. Biochem. Biophys. Res. Commun. 2006 Nov 3; 349(4): 1235-41. Epub 2006 Sep 1.
27.    Ping Wang, Zhaojun Zhang and Biao Yu. Total synthesis of CRM646-A, B. J .Org. Chem. 2005, 70(22), 8884-8889.
28.    Biao Yu and Ping Wang. Efficient synthesis of the Hexasaccharide Fragment of Landomycin A: Using Phenyl 2,3-O-Thionocarbonyl-1-thioglycosides as 2-Deoxy-β-glycosides Precursors. Org. Lett. 2002, 4, 1919-1922.
Patent
29.    Jeffrey V. Ravetch, Andrew Pincetic, Ping Wang, Samuel J. Danishefsky,Human DC-SIGN binding peptides derived from IgG1 Fc fragment. PCT Int. Appl. 2013, WO 2013095973 A1 20130627.
30.    Samuel J. Danishefsky, Ping Wang, Suwei Dong, Malcolm A. Moore, Jaehung Shieh, John A. Brailsford,. Homogenous and fully glycosylated human erythropoietin. PCT Int. Appl. (2013), WO 2013166053 A2 20131107. 

 

 




7. 其他
    欢迎对有机合成,糖化学、多肽合成以及相关化学生物学感兴趣的同学报考本组硕士、博士研究生和从事博士后研究。





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很很鲁很很鲁视在线视频|香蕉伊人不卡在线看|天天鲁啪视频在线

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地址:上海市东川路800号 200240

电话:021-54742893

E-mail:sjtuscce@sjtu.edu.cn